5 min read

Biotech iQ Recap for the Week Ending June 6, 2025

Welcome to the BiQ Weekly Recap #20!

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Weekly Overview

The index closed last Friday at 79.16, opened Monday at 80.20, and closed Friday at 84.25 for a weekly gain of 6.4%. It reached an intra-week high of 84.45 and a low of 79.49 for an intra-week range of 6.2%.

XBI 5-Day Chart. Click image to enlarge.

Zooming out to the one-year chart, we can see that the index closed Friday at a key resistance level, and it will be very interesting to see where the index goes from here. I believe markets still face significant headwinds from ongoing trade negotiations, ongoing uncertainty regarding the future direction of the FDA, and the potential fallout from MFN. We still have a long way to go before we're clear of these headwinds, and it will take time to work through these uncertainties. I continue to maintain elevated liquidity levels and aggressively sell Call options while waiting for the index to find its footing.

XBI 1-Year Chart. Click image to enlarge.

Zooming out further to the five-year chart, we can see that the index has bounced off the 64 to 66 level three times: in June 2022, October 2023, and most recently in April 2025. While I am cautiously hopeful that we may see a recovery to the 88-90 resistance level, volatility remains elevated, and it's equally possible the index revisits recent lows. It's tough to make any predictions, so my portfolio positioning remains cautious.

XBI 5-Year Chart with RSI. Click image to enlarge.

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BiQ Realized Gains & Losses

Biotech iQ is oriented towards long-term investing; it is not a short-term or active trading service. Typically, I only fully exit positions when the long-term thesis and risk/reward no longer appear attractive. The BiQ Realized Gains & Losses spreadsheet displays all realized gains and losses since BiQ was launched in 2024. Premium members can also view the current performance of the BiQ Active Portfolio on the Active Portfolio page of the Biotech iQ website.

Click image to enlarge.

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